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Decreased kidney function increases the risk of developing dementia ... a study reveals


A new study by the Karolinska Institute in Stockholm, Sweden, revealed that people who suffer from chronic kidney disease and decreased kidney function are more likely to develop dementia, and chronic kidney disease occurs when a person's kidneys gradually lose their ability to filter waste from the blood and get rid of fluids, and the study found that people who suffer Those who have impaired kidney function may be more likely to develop dementia.


"Even a slight decrease in kidney function has been linked to an increased risk of cardiovascular disease and inflammation," said study author Hong Xu of the Karolinska Institute in Stockholm, Sweden, said study author Hong Xu, who was linked to an increased risk of cardiovascular disease and infections, and there is growing evidence of a relationship between the kidneys and the brain.


The study showed that, in addition to chronic kidney disease, the risk of developing dementia increases with age, with no effective treatments to slow or prevent dementia. It is important to identify potential risk factors that are modifiable if we can prevent or delay some cases of dementia by preventing or treating kidney disease. Therefore, this may have important public health benefits. Our study shows that decreased kidney function is associated with the development of dementia, but it does not prove that it is a cause.


During the study, the researchers used a database to identify approximately 330,000 people aged 65 or over who received health care in Stockholm, and were followed for an average of five years. None of the participants had dementia, or underwent kidney transplantation or dialysis. At the start of the study over the course of the study, 18,983 people, or 6% of the participants, were diagnosed with dementia.


Using blood tests for plasma creatinine, the researchers estimated the glomerular filtration rate for each participant, which is a measure of how well the blood is filtered through the kidneys, and is often used to approximate kidney function. A filtration rate of 90 milliliters (ml) per minute or higher is normal in most healthy people.


Using this measure, the researchers then determined rates of dementia in people with different levels of kidney function.


The researchers found that with reduced kidney function, the rate of dementia increased in people with a normal kidney filtration rate from 90 to 104 ml per minute, and there were seven cases of dementia per 1,000 person / year in people with severe kidney disease, and a lower filtration rate. From 30 ml per minute there were 30 cases of dementia per 1000 person / year.

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